MAP3K3 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: mitogen-activated protein kinase kinase kinase 3
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 74 kDa
Uniprot: Q99759
Gene id: 4215
Background: The mitogen-activated protein
ERK kinase kinase 3(MEKK3) is a member of a family of MEKK
Ste11 serine
threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.(PMID: 18206350).Cerebral cavernous malformations(CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2
4 may be targeted to develop new CCM therapeutics.
Field of research: Signal Transduction, Immunology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:200-1:2000; IHC: 1:50-1:500
Target: MAP3K3
Purification: Immunogen affinity purified
Reactivity: Human
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: mitogen-activated protein kinase kinase kinase 3
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 74 kDa
Uniprot: Q99759
Gene id: 4215
Background: The mitogen-activated protein
ERK kinase kinase 3(MEKK3) is a member of a family of MEKK
Ste11 serine
threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.(PMID: 18206350).Cerebral cavernous malformations(CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2
4 may be targeted to develop new CCM therapeutics.
Field of research: Signal Transduction, Immunology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:200-1:2000; IHC: 1:50-1:500
Target: MAP3K3
Purification: Immunogen affinity purified
Reactivity: Human