CD22 antibody - 100 µg
Host : Mouse
Clonality: Monoclonal
Clone: 7D10
Isotype: IgG1
Immunogen: CD22 molecule
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 135 kDa
Uniprot: P20273
Gene id: 933
Background: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Field of research: Stem Cells, Immunology, Signal Transduction, Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB : 1:1000-1:10000; IHC : 1:500-1:2000
Target: CD22
Purification: Protein A+G purification
Reactivity: Human
![]()
Clonality: Monoclonal
Clone: 7D10
Isotype: IgG1
Immunogen: CD22 molecule
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 135 kDa
Uniprot: P20273
Gene id: 933
Background: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Field of research: Stem Cells, Immunology, Signal Transduction, Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB : 1:1000-1:10000; IHC : 1:500-1:2000
Target: CD22
Purification: Protein A+G purification
Reactivity: Human